abstract：Background:Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors in the world, and it has become the leading cause of death of malignant tumors. However, its mechanisms are not fully clear. The aim of this study is to investigate the key genes and explore their potential mechanisms involving in ...

journal_title：PeerJ

authors： Zhang L,Peng R,Sun Y,Wang J,Chong X,Zhang Z

更新日期：2019-12-12 00:00:00

abstract：:Motor unit synchronization is the tendency of motor neurons and their associated muscle fibers to discharge near-simultaneously. It has been theorized as a control mechanism for force generation by common excitatory inputs to these motor neurons. Magnitude of synchronization is calculated from peaks in cross-correlati...

journal_title：PeerJ

authors： Tweedell AJ,Tenan MS

更新日期：2019-12-10 00:00:00

abstract：:In this study, silver nanoparticles (NP) were synthesized by two methods: using an aqueous extract of Mentha spicata leaves and using citrate ions as stabilizing agent, and the cytotoxicity and anticancer activity of both NP were evaluated in vitro. The particles synthesized with the aqueous extract were spherical wit...

journal_title：PeerJ

authors： Torres-Martínez Y,Arredondo-Espinoza E,Puente C,González-Santiago O,Pineda-Aguilar N,Balderas-Rentería I,López I,Ramírez-Cabrera MA

更新日期：2019-12-09 00:00:00

abstract：Background:Understanding individual food preferences is critical for creating tailored strategies that promote healthy individual eating behaviors. Individual sensory liking appears to be an essential determinant of dietary intake. Taste preferences influence satisfaction and satiety, and may consequently influence wei...

journal_title：PeerJ

authors： Petre LM,Vatasescu BN

更新日期：2019-12-06 00:00:00

abstract：:Although the cellular and molecular responses to exposure to relatively high temperatures (acute thermal stress or heat shock) have been studied previously, only sparse empirical evidence of how it affects cold-water species is available. As climate change becomes more pronounced in areas such as the Western Antarctic...

journal_title：PeerJ

authors： González-Aravena M,Kenny NJ,Osorio M,Font A,Riesgo A,Cárdenas CA

更新日期：2019-12-03 00:00:00

abstract：Background:Proper glycemic control is an important goal of critical care medicine, including perioperative patient care that can influence patients' prognosis. Insulin secretion from pancreatic β-cells is generally assumed to play a critical role in glycemic control in response to an elevated blood glucose concentratio...

journal_title：PeerJ

authors： Kusunoki M,Hayashi M,Shoji T,Uba T,Tanaka H,Sumi C,Matsuo Y,Hirota K

更新日期：2019-12-02 00:00:00

abstract：Background:Current and future changes in rainfall amount and frequency may particularly impact annual plants in desert ecosystems. The winter annual Echinops gmelinii Turcz. is widely distributed in the desert habitats of northern China and is a dominant pioneer annual plant following sand stabilization in the Tengger ...

journal_title：PeerJ

authors： Wang Y,Li X,Liu L,Zhao J,Sun J

更新日期：2019-11-29 00:00:00

abstract：:Chloroplasts are typically inherited from the female parent and are haploid in most angiosperms, but rare intra-individual heteroplasmy in plastid genomes has been reported in plants. Here, we report an example of plastome heteroplasmy and its characteristics in Gentiana tongolensis (Gentianaceae). The plastid genome ...

journal_title：PeerJ

authors： Sun SS,Zhou XJ,Li ZZ,Song HY,Long ZC,Fu PC

更新日期：2019-11-27 00:00:00

abstract：Background:This study sought to better understand the psychometric properties of the SARC-F, by examining the baseline and training-related relationships between the five SARC-F items and objective measures of muscle function. Each of the five items of the SARC-F are scored from 0 to 2, with total score of four or more...

journal_title：PeerJ

authors： Keogh JWL,Henwood T,Gardiner PA,Tuckett AG,Hetherington S,Rouse K,Swinton P

更新日期：2019-11-27 00:00:00

abstract：Background:The exoskeleton of an insect could be an important factor in the success of its evolutionary process. This reaches its maximum expression in beetles, which constitute the most diversified animal taxon. The involvement in the management of environmental radiation could be one of the most important functions o...

journal_title：PeerJ

authors： Cuesta E,Lobo JM

更新日期：2019-11-25 00:00:00

abstract：Background:In the predator-sea urchin-macrophyte trophic cascade, the ecological effect of sea urchins as grazers depends both on their density and the changes in foraging activity, which are influenced by various disturbing factors. However, the complete duration of the alarm reactions of echinoids has not been studie...

journal_title：PeerJ

authors： Zhadan PM,Vaschenko MA

更新日期：2019-11-22 00:00:00

abstract：Background:Recent studies have shown that people with high alexithymia scores have decreased interoceptive abilities, which can be associated with psychological and physical disorders. Early assessments of the alexithymia trait included the evaluation of these abilities through the dimension measuring the difficulty in...

journal_title：PeerJ

authors： Fournier A,Luminet O,Dambrun M,Dutheil F,Pellissier S,Mondillon L

更新日期：2019-11-20 00:00:00

abstract：:A new species of the genus Mesacanthion Filipjev, 1927 was discovered during a survey of natural beaches of Jeju Island in South Korea. The new species Mesacanthion jejuensissp. nov. shares general morphology of the genus such as the outer labial and cephalic setae being situated at the middle of cephalic capsule, wel...

journal_title：PeerJ

authors： Jeong R,Tchesunov AV,Lee W

更新日期：2019-11-18 00:00:00

abstract：Background:Sacbrood virus (SBV) is one of the most pathogenic honeybee viruses that exhibits host specificity and regional variations. The SBV strains that infect the Chinese honeybee Apis cerana are called Chinese SBVs (CSBVs). Methods:In this study, a CSBV strain named AmCSBV-SDLY-2016 (GenBank accession No. MG73328...

journal_title：PeerJ

authors： Li M,Fei D,Sun L,Ma M

更新日期：2019-11-14 00:00:00

abstract：Background:In horses and ponies numerous medical conditions are known to be linked with inflammation in different tissues, especially in the liver. Besides affecting other metabolic pathways such as the expression of certain interleukins (IL), inflammation is associated with stress of the endoplasmic reticulum (ER). In...

journal_title：PeerJ

authors： Starzonek J,Roscher K,Blüher M,Blaue D,Schedlbauer C,Hirz M,Raila J,Vervuert I

更新日期：2019-11-12 00:00:00

abstract：:Flatfish undergo extreme morphological development and settle to a benthic in the adult stage, and are likely to be more susceptible to environmental stress. Heat shock proteins 70 (hsp70) are involved in embryonic development and stress response in metazoan animals. However, the evolutionary history and functions of ...

journal_title：PeerJ

authors： Liu K,Hao X,Wang Q,Hou J,Lai X,Dong Z,Shao C

更新日期：2019-11-11 00:00:00

abstract：:China has experienced intensive urbanization over the past decades. However, it is still unclear about the influence of urbanization on urban thermal comfort and how the effect varies with climate condition. Based on long-term daily meteorological data from 1990 to 2015 in four Chinese cities undergoing rapid urbaniza...

journal_title：PeerJ

authors： Fu Y,Ren Z,Yu Q,He X,Xiao L,Wang Q,Liu C

更新日期：2019-11-11 00:00:00

abstract：:A fundamental question in ecology is how the success of a taxon changes through time and what drives this change. This question is commonly approached using trajectories averaged over a group of taxa. Using results from probability theory, we show analytically and using examples that averaged trajectories will be more...

journal_title：PeerJ

authors： Hohmann N,Jarochowska E

更新日期：2019-11-06 00:00:00

abstract：:Callinectes sapidus Rathbun, 1896 is a western Atlantic species with a disjointed natural geographic range from Massachusetts, USA to Venezuela (distribution area 1) and from Alagoas, Brazil to northern Argentina (distribution area 2). It is the only species of portunid crab commercially harvested in the continental U...

journal_title：PeerJ

authors： Windsor AM,Moore MK,Warner KA,Stadig SR,Deeds JR

更新日期：2019-11-05 00:00:00

abstract：Background:Using wearable inertial sensors to accurately estimate energy expenditure (EE) during an athletic training process is important. Due to the characteristics of inertial sensors, however, the positions in which they are worn can produce signals of different natures. To understand and solve this issue, this stu...

journal_title：PeerJ

authors： Ho CS,Chang CH,Lin KC,Huang CC,Hsu YJ

更新日期：2019-11-04 00:00:00

abstract：Background:As the most frequently occurred tumor in biliary tract, cholangiocarcinoma (CCA) is mainly characterized by its late diagnosis and poor outcome. It is therefore urgent to identify specific genes and pathways associated with its progression and prognosis. Materials and Methods:The differentially expressed ge...

journal_title：PeerJ

authors： Liu J,Liu W,Li H,Deng Q,Yang M,Li X,Liang Z

更新日期：2019-10-31 00:00:00

abstract：Background:The problem of access to medical information, particularly in low-income countries, has been under discussion for many years. Although a number of developments have occurred in the last decade (e.g., the open access (OA) movement and the website Sci-Hub), everyone agrees that these difficulties still persist...

journal_title：PeerJ

authors： Boudry C,Alvarez-Muñoz P,Arencibia-Jorge R,Ayena D,Brouwer NJ,Chaudhuri Z,Chawner B,Epee E,Erraïs K,Fotouhi A,Gharaibeh AM,Hassanein DH,Herwig-Carl MC,Howard K,Kaimbo Wa Kaimbo D,Laughrea PA,Lopez FA,Machin-Mastromatteo

更新日期：2019-10-30 00:00:00

abstract：:Loot boxes are items in video games that may be paid for with real-world money, but which contain randomised contents. There is a reliable correlation between loot box spending and problem gambling severity: the more money gamers spend on loot boxes, the more severe their problem gambling tends to be. However, it is u...

journal_title：PeerJ

authors： Zendle D

更新日期：2019-10-29 00:00:00

abstract：:The number of people suffering from eye fatigue induced by visual display terminal (VDT) viewing is expected to increase in the modern world. Eye dysfunction is suggested to induce a decrease in cognitive function, at least in the long term. Furthermore, considering other previous findings, it may be reasonable to thi...

journal_title：PeerJ

authors： Akagi R,Tonotsuka M,Horie R,Hirata K,Ando S

更新日期：2019-10-29 00:00:00

abstract：:It is assumed that the sequencing of ribosomes better reflects the active microbial community than the sequencing of the ribosomal RNA encoding genes. Yet, many studies exploring microbial communities in various environments, ranging from the human gut to deep oceans, questioned the validity of this paradigm due to th...

journal_title：PeerJ

authors： Šťovíček A,Cohen-Chalamish S,Gillor O

更新日期：2019-10-25 00:00:00

abstract：:Osteogenic cells form mineralized matrices in vitro, as well as in vivo. The formation and shape of the mineralized matrices are highly regulated by the cells. In vitro formation of mineralized matrices by osteogenic cells can be a model for in vivo osteogenesis. In this study, using a three-dimensional (3D) collagen ...

journal_title：PeerJ

authors： Kihara T,Umezu C,Sawada K,Furutani Y

更新日期：2019-10-23 00:00:00

abstract：Background:DegS is a periplasmic serine protease that is considered to be the initiator of the σE stress response pathway, and this protein plays an important role in the regulation of the stress response in E. coli. However, knowledge of the biological function and global regulatory network of DegS in Vibrio cholerae ...

journal_title：PeerJ

authors： Huang J,Chen Y,Chen J,Liu C,Zhang T,Luo S,Huang M,Min X

更新日期：2019-10-23 00:00:00

abstract：:The Asian clam, Corbicula fluminea, is a commonly consumed small freshwater bivalve in East Asia. However, available genetic information of this clam is still limited. In this study, the transcriptome of female C. fluminea was sequenced using the Illumina HiSeq 2500 platform. A total of 89,563 unigenes were assembled ...

journal_title：PeerJ

authors： Zhu C,Zhang L,Ding H,Pan Z

更新日期：2019-10-22 00:00:00

abstract：:According to the intelligence-creativity threshold hypothesis, there should be a positive association between intelligence and creative potential up to a certain point, the threshold, after which a further increase in intelligence should have no association with creativity. In the present simulation study, the measure...

journal_title：PeerJ

authors： Sorjonen K,Ingre M,Melin B

更新日期：2019-10-21 00:00:00

abstract：:This work was aimed to investigate the effects of the different particle size of ground alfalfa hay on caecal microbial and archeal communities of rabbits. One hundred-twenty New Zealand rabbits (950.3 ± 8.82 g) were allocated into four treatments, with five replicates in each treatment and six rabbits in each replica...

journal_title：PeerJ

authors： Yuan M,Liu S,Wang Z,Wang L,Xue B,Zou H,Tian G,Cai J,Peng Q

更新日期：2019-10-18 00:00:00

abstract：Background & Aims:Endothelial precursor cell (EPC) dysfunction is one of the risk factors for diabetes mellitus (DM) which results in delayed wound healing. Rosiglitazone (RSG) is a frequently prescribed oral glucose-lowering drug. Previous studies have shown the positive effects of RSG on ameliorating EPC dysfunction ...

journal_title：PeerJ

authors： Zhou G,Han X,Wu Z,Shi Q,Bao X

更新日期：2019-10-17 00:00:00

abstract：:Preserved labile tissues (e.g., skin, muscle) in the fossil record of terrestrial vertebrates are increasingly becoming recognized as an important source of biological and taphonomic information. Here, we combine a variety of synchrotron radiation techniques with scanning electron and optical microscopy to elucidate t...

journal_title：PeerJ

authors： Barbi M,Bell PR,Fanti F,Dynes JJ,Kolaceke A,Buttigieg J,Coulson IM,Currie PJ

更新日期：2019-10-16 00:00:00

abstract：Background:The WRKY transcription factor family plays crucial roles in many aspects of physiological processes and adaption to environment. Although the WRKY genes have been widely identified in various plant species, the structure and function of the WRKY family in sugar beet (Beta vulgaris L.) remains unknown. Metho...

journal_title：PeerJ

authors： Wu GQ,Li ZQ,Cao H,Wang JL

更新日期：2019-10-14 00:00:00

abstract：Background:Mimusops coriacea (A.DC.) Miq., (Sapotaceae), originated from Africa, were introduced to coastal areas in Ecuador where it is not extensively used as a traditional medicine to treat various human diseases. Different therapeutically uses of the species include: analgesic, antimicrobial, hypoglycemic, inflamma...

journal_title：PeerJ

authors： Bustamante K,Santos-Ordóñez E,Miranda M,Pacheco R,Gutiérrez Y,Scull R

更新日期：2019-10-11 00:00:00

abstract：:In this study, we propose and test a novel ensemble method for improving the accuracy of each method in flood susceptibility mapping using evidential belief function (EBF) and support vector machine (SVM). The outcome of the proposed method was compared with the results of each method. The proposed method was implemen...

journal_title：PeerJ

authors： Shafapour Tehrany M,Kumar L,Shabani F

更新日期：2019-10-09 00:00:00

abstract：Background:Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed class of drugs in the practice of psychiatry. Cytochrome P450 (CYP) 2C19 and CYP2D6 are established as clinically relevant drug metabolizing enzymes (DMEs) that influence the pharmacokinetics of SSRIs and may either be group...

journal_title：PeerJ

authors： Eugene AR

更新日期：2019-10-09 00:00:00

abstract：:Hydrozoa medusae undergo blooms and seasonal fluctuations; however the drivers of such fluctuations are unknown. To understand how medusa populations fluctuate in response to seasonal factors such as temperature, salinity, dissolved oxygen, and chlorophyll a, and to enhance our taxonomic knowledge of Hydrozoa in Galve...

journal_title：PeerJ

authors： Pruski S,Miglietta MP

更新日期：2019-10-08 00:00:00

abstract：:Metabarcoding can rapidly determine the species composition of bulk samples and thus aids biodiversity and ecosystem assessment. However, it is essential to use primer sets that minimize amplification bias among taxa to maximize species recovery. Despite this fact, the performance of primer sets employed for metabarco...

journal_title：PeerJ

authors： Elbrecht V,Braukmann TWA,Ivanova NV,Prosser SWJ,Hajibabaei M,Wright M,Zakharov EV,Hebert PDN,Steinke D

更新日期：2019-10-07 00:00:00

abstract：Objective:To synthetize the scientific evidence on the association between serum lipids and premature mortality in Latin America (LA). Methods:Five data bases were searched from inception without language restrictions: Embase, Medline, Global Health, Scopus and LILACS. Population-based studies following random samplin...

journal_title：PeerJ

authors： Carrillo-Larco RM,Albitres-Flores L,Barengo NC,Bernabe-Ortiz A

更新日期：2019-10-04 00:00:00

abstract：:Live trapping is a common tool used to assess demography of small mammals. However, live-trapping is often expensive and stressful to captured individuals. Thus, assessing the relative tradeoffs among study goals, project expenses, and animal well-being is necessary. Here, we evaluated how apparent bias and precision ...

journal_title：PeerJ

authors： Weldy MJ,Wilson TM,Lesmeister DB,Epps CW

更新日期：2019-10-03 00:00:00